Prof. Limor Broday

Limor Broday is an Associate Professor at the Gray Faculty of Medical and Health Sciences, Tel Aviv University. She obtained her Ph.D. in Genetics from the Technion – Israel Institute of Technology and trained as a post-doctoral fellow at NYU Medical Center and Mount Sinai Medical Center, New York, NY.

Prof. Broday laboratory uses the nematode C. elegans and the planarian Schmidtea mediterranea to understand how post-translational modifications by SUMO, the Small Ubiquitin-like Modifier, are regulated.

Her discoveries in these model systems have been independently validated by international research groups, demonstrating their conservation in humans and their significance in both normal physiology and various diseases.

More recently, the Broday's group uses patient-derived cancer cell cultures to study impaired phosphorylation processes initiated by oncogenic gene fusions with constitutive tyrosine-kinase activity, focusing on EML4-ALK, a known somatic driver in lung adenocarcinoma.

In parallel, the group has developed a rapid drug screening strategy using cells from malignant pleural effusions, designed to support oncologists in making informed treatment decisions. Keywords: SUMO (small ubiquitin-like modifier), Caenorhabditis elegans, Germline, Schmidtea mediterranea, EML4-ALK oncogene, malignant pleural effusion, personalized medicine